Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins
نویسندگان
چکیده
منابع مشابه
Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix.
Human glomerular mesangial cells (HMC) are embedded in the mesangial matrix (MM) and control its turnover through a dynamic equilibrium between synthesis and degradation. Degradation is controlled by matrix metalloproteinases (MMP), whose activity has been causally implicated in the progression of glomerular disease. In other systems, MMP secretion may be directly affected by exposure to specif...
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Biomedical research is often thought to primarily focus upon the trillions of cells that make up the body. However just as study of the immune system cannot ignore the lymph in favor of blood, the extracellular matrix (ECM) cannot be ignored in favor of the cells. The ECM is a dynamic structure that acts as scaffolding substrate for cell adhesion, as well as a reservoir of various proteins, gro...
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Exposure of the human skin to acute solar ultraviolet (UV) irradiation induces several members of the matrix metalloproteinase family (MMPs), which degrade collagen fibrils and other components of the dermal extracellular matrix (ECM) (Fisher et al., 1996; Yaar and Gilchrest, 2007). Elevation of MMPs due to chronic sun exposure can promote accumulation of dermal ECM fragmentation, which contrib...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2019
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2018.11.024